CNS complications of radiotherapy and chemotherapy
- PMID: 19897130
- DOI: 10.1016/S0140-6736(09)61299-X
CNS complications of radiotherapy and chemotherapy
Abstract
Treatment-induced CNS toxicity remains a major cause of morbidity in patients with cancer. Advances in the design of safe radiation procedures have been counterbalanced by widespread use of combined radiotherapy and chemotherapy, development of radiosurgery, and the increasing number of long-term survivors. Although classic radionecrosis and chemonecrosis have become less common, subtle changes such as progressive cognitive dysfunction are increasingly reported after radiotherapy (radiation-induced leukoencephalopathy) or chemotherapy (given alone or in combination). We review the most important and controversial complications of radiotherapy, chemotherapy, and combined treatments in the CNS, and discuss new diagnostic tools, practical management, prevention, and pathophysiological data that will affect future management of patients with cancer.
Similar articles
-
Neurotoxicity of the CNS: diagnosis, treatment and prevention.Rev Neurol (Paris). 2011 Oct;167(10):737-45. doi: 10.1016/j.neurol.2011.08.005. Epub 2011 Sep 6. Rev Neurol (Paris). 2011. PMID: 21899866 Review.
-
Brain damage from anticancer treatments in adults.Curr Opin Oncol. 2009 Nov;21(6):559-65. doi: 10.1097/CCO.0b013e328330c669. Curr Opin Oncol. 2009. PMID: 19667984 Review.
-
Central nervous system complications of cancer therapy.J Support Oncol. 2012 Jul-Aug;10(4):133-41. doi: 10.1016/j.suponc.2011.11.002. Epub 2012 Apr 27. J Support Oncol. 2012. PMID: 22542045 Review.
-
Late complications in childhood central nervous system tumour survivors.Curr Opin Neurol. 2003 Dec;16(6):677-83. doi: 10.1097/01.wco.0000102623.38669.e5. Curr Opin Neurol. 2003. PMID: 14624076 Review.
-
Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy.Oncologist. 2008 Dec;13(12):1285-95. doi: 10.1634/theoncologist.2008-0130. Epub 2008 Nov 19. Oncologist. 2008. PMID: 19019972 Review.
Cited by
-
Value of DWI Combined with Magnetic Resonance Spectroscopy in the Differential Diagnosis between Recurrent Glioma and Radiation Injury: A Meta-Analysis.Int J Clin Pract. 2022 Oct 25;2022:1629570. doi: 10.1155/2022/1629570. eCollection 2022. Int J Clin Pract. 2022. PMID: 36380750 Free PMC article. Review.
-
Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling.Geroscience. 2021 Feb;43(1):197-212. doi: 10.1007/s11357-020-00289-8. Epub 2020 Oct 22. Geroscience. 2021. PMID: 33094399 Free PMC article.
-
Mental health care in oncology. Contemporary perspective on the psychosocial burden of cancer and evidence-based interventions.Epidemiol Psychiatr Sci. 2020 Jan 9;29:e86. doi: 10.1017/S2045796019000866. Epidemiol Psychiatr Sci. 2020. PMID: 31915100 Free PMC article.
-
Reduced-dose WBRT as consolidation treatment for patients with primary CNS lymphoma: an LOC network study.Blood Adv. 2022 Aug 23;6(16):4807-4815. doi: 10.1182/bloodadvances.2022007011. Blood Adv. 2022. PMID: 35772168 Free PMC article.
-
Early toxicity predicts long-term survival in high-grade glioma.Br J Cancer. 2011 Apr 26;104(9):1365-71. doi: 10.1038/bjc.2011.123. Epub 2011 Apr 12. Br J Cancer. 2011. PMID: 21487410 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical