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. 2010 Jan;38(Database issue):D532-9.
doi: 10.1093/nar/gkp983. Epub 2009 Nov 6.

MINT, the molecular interaction database: 2009 update

Arnaud Ceol  1 , Andrew Chatr Aryamontri, Luana Licata, Daniele Peluso, Leonardo Briganti, Livia Perfetto, Luisa Castagnoli, Gianni Cesareni
Affiliations

MINT, the molecular interaction database: 2009 update

Arnaud Ceol et al. Nucleic Acids Res. 2010 Jan.

Abstract

MINT (http://mint.bio.uniroma2.it/mint) is a public repository for molecular interactions reported in peer-reviewed journals. Since its last report, MINT has grown considerably in size and evolved in scope to meet the requirements of its users. The main changes include a more precise definition of the curation policy and the development of an enhanced and user-friendly interface to facilitate the analysis of the ever-growing interaction dataset. MINT has adopted the PSI-MI standards for the annotation and for the representation of molecular interactions and is a member of the IMEx consortium.

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Figures

Figure 1.
Figure 1.
Exploring the EGFR pathway in MINT. In panel (a) the EFGR pathway interactome is shown. The network in panel (b) is obtained by removing interactions below a certain confidence threshold (0.72).
Figure 2.
Figure 2.
Proteins partners of the E3 ubiquitin-protein ligase CBL. In the right frame interactors are ordered according to the MINT score. The total number of evidences is provided as well as the number of direct interactions, physical associations (the two PSI-MI terms physical association and association are grouped here), colocalizations and enzymatic reactions. Even if enzymatic reactions are considered according to PSI-MI standard as a subtype of direct interactions, there are counted here only as enzymatic reaction. The number of evidences by high throughput experiment and the number of evidences in which the two proteins are part of a larger complex are indicated in the last two columns. Each figure in the different columns is linked to the description of the evidences supporting the interaction. By clicking the ‘22’ link on the first row one obtains the information in the the left frame where the evidences for SH3KBP1 as a partner of CBL are grouped by publication and detection method.
Figure 3.
Figure 3.
The ‘connect’ tool. The network is obtained by searching for 13 SH3 containing proteins. The node size has been reduced to the minimum with the scrollbar to provide a lighter view of the network. The proteins in the query are identified by a yellow border.
See this image and copyright information in PMC

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