Inflammatory markers and outcomes in cardiovascular disease

doi:10.1371/journal.pmed.1000147

Comment

. 2009 Sep;6(9):e1000147.

doi: 10.1371/journal.pmed.1000147. Epub 2009 Sep 8.

Inflammatory markers and outcomes in cardiovascular disease

Leonard Kritharides¹

Affiliations

Affiliation

¹ Department of Cardiology Concord Repatriation General Hospital, Sydney South Western Area Health Service, University of Sydney, New South Wales, Australia. lenk@med.usyd.edu.au

PMID: 19901972
PMCID: PMC2730031
DOI: 10.1371/journal.pmed.1000147

Comment

Inflammatory markers and outcomes in cardiovascular disease

Leonard Kritharides. PLoS Med. 2009 Sep.

. 2009 Sep;6(9):e1000147.

doi: 10.1371/journal.pmed.1000147. Epub 2009 Sep 8.

Author

Leonard Kritharides¹

Affiliation

¹ Department of Cardiology Concord Repatriation General Hospital, Sydney South Western Area Health Service, University of Sydney, New South Wales, Australia. lenk@med.usyd.edu.au

PMID: 19901972
PMCID: PMC2730031
DOI: 10.1371/journal.pmed.1000147

Abstract

In a prospective cohort study of patient outcomes following stroke, William Whiteley and colleagues find that markers of inflammatory response are associated with poor outcomes. However, addition of these markers to existing prognostic models does not improve outcome prediction.

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Conflict of interest statement

The author has declared that no competing interests exist.

Comment on

Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6.
Whiteley W, Jackson C, Lewis S, Lowe G, Rumley A, Sandercock P, Wardlaw J, Dennis M, Sudlow C. Whiteley W, et al. PLoS Med. 2009 Sep;6(9):e1000145. doi: 10.1371/journal.pmed.1000145. Epub 2009 Sep 8. PLoS Med. 2009. PMID: 19901973 Free PMC article.

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References

1. Tedgui A, Mallat Z. Cytokines in atherosclerosis: Pathogenic and regulatory pathways. Physiol Rev. 2006;86:515–581. - PubMed
1. Ridker PM BJ, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation. 2003;107:391–397. - PubMed
1. Sabatine MS, Morrow DA, Jablonski KA, Rice MM, Warnica JW, et al. Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease. Circulation. 2007;115:1528–1536. - PubMed
1. Di Napoli M, Schwaninger M, Cappelli R, Ceccarelli E, Di Gianfilippo G, et al. Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke. 2005;36:1316–1329. - PubMed
1. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N EnglJ Med. 2004;350:1387–1389. - PubMed

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[1] Tedgui A, Mallat Z. Cytokines in atherosclerosis: Pathogenic and regulatory pathways. Physiol Rev. 2006;86:515–581. - PubMed

[2] Tedgui A, Mallat Z. Cytokines in atherosclerosis: Pathogenic and regulatory pathways. Physiol Rev. 2006;86:515–581. - PubMed

[3] Ridker PM BJ, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation. 2003;107:391–397. - PubMed

[4] Ridker PM BJ, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation. 2003;107:391–397. - PubMed

[5] Sabatine MS, Morrow DA, Jablonski KA, Rice MM, Warnica JW, et al. Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease. Circulation. 2007;115:1528–1536. - PubMed

[6] Sabatine MS, Morrow DA, Jablonski KA, Rice MM, Warnica JW, et al. Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease. Circulation. 2007;115:1528–1536. - PubMed

[7] Di Napoli M, Schwaninger M, Cappelli R, Ceccarelli E, Di Gianfilippo G, et al. Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke. 2005;36:1316–1329. - PubMed

[8] Di Napoli M, Schwaninger M, Cappelli R, Ceccarelli E, Di Gianfilippo G, et al. Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke. 2005;36:1316–1329. - PubMed

[9] Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N EnglJ Med. 2004;350:1387–1389. - PubMed

[10] Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N EnglJ Med. 2004;350:1387–1389. - PubMed

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Inflammatory markers and outcomes in cardiovascular disease

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Inflammatory markers and outcomes in cardiovascular disease

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