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. 2010:2010:392652.
doi: 10.1155/2010/392652. Epub 2009 Nov 5.

Circulating tumor cells in gastrointestinal malignancies: current techniques and clinical implications

Georg Lurje  1 , Marc Schiesser, Andreas Claudius, Paul Magnus Schneider
Affiliations

Circulating tumor cells in gastrointestinal malignancies: current techniques and clinical implications

Georg Lurje et al. J Oncol. 2010.

Abstract

Since their introduction more than 50 years by Engell, circulating tumor cells (CTCs) have been evaluated in cancer patients and their detection has been correlated with clinical outcome, in esophageal, gastric, and colorectal cancer. With the availability of refined technologies, the identification of CTCs from peripheral blood is emerging as a useful tool for the detection of malignancy, monitoring disease progression, and measuring response to therapy. However, increasing evidence suggests a variety of factors to be responsible for disease progression. The analysis of a single CTC marker is therefore unlikely to accurately predict progression of disease with sufficient resolution and reproducibility. Here we discuss the current concept of CTCs, summarize the available techniques for their detection and characterization, and aim to provide a comprehensive update on the clinical implications of CTCs in gastrointestinal (GI) malignancies.

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References

    1. Engell HC. Cancer cells in the circulating blood; a clinical study on the occurrence of cancer cells in the peripheral blood and in venous blood draining the tumour area at operation. Ugeskr Laeger. 1955;117:822–823. - PubMed
    1. Ulmer A, Schmidt-Kittler O, Fischer J, et al. Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cells. Clinical Cancer Research. 2004;10(2):531–537. - PubMed
    1. Fehm T, Sagalowsky A, Clifford E, et al. Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant. Clinical Cancer Research. 2002;8(7):2073–2084. - PubMed
    1. Folkman J. Tumor angiogenesis: therapeutic implications. The New England Journal of Medicine. 1971;285(21):1182–1186. - PubMed
    1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Medicine. 1995;1(1):27–31. - PubMed