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. 2008 Jul;28(3):95-9.
doi: 10.4103/0973-3930.44081.

Celiac disease in patients with type-1 diabetes mellitus screened by tissue transglutaminase antibodies in northwest of Iran

Nasrin Sharifi, Manouchehr Khoshbaten, Akbar Aliasgarzade, Amir Bahrami

Celiac disease in patients with type-1 diabetes mellitus screened by tissue transglutaminase antibodies in northwest of Iran

Nasrin Sharifi et al. Int J Diabetes Dev Ctries. 2008 Jul.

Abstract

Background: High prevalence rates of celiac disease (CD) in patients with type-1 diabetes mellitus (T1DM) have been reported in several countries. However, the data regarding this association are scarce in Iran. In this study, we report the prevalence of CD in patients with T1DM in northwest of Iran using tissue transglutaminase antibodies (tTGA) as a screening test.

Methodology: One hundred patients with T1DM (58 women and 42 men) aged 21.8 +/- 8.86 years (age range: 7-50 years) were compared with 150 healthy people (82 women and 68 men) aged 28.9 +/- 9.07 years (age range: 4-50 years). All subjects were serologically screened for the presence of tTGA. Total immunoglobin A (IgA) was obtained to investigate IgA deficiency. Subjects positive for tTGA and deficient for IgA were submitted to upper gastrointestinal endoscopy.

Results: Eight patients with T1DM (8%) and three of the controls (2%) were positive for tTGA (P = 0.023), while only 3% of the tTGA positive T1DM patients underwent duodenal biopsy and all of them showed partial or total villous atrophy. The mean age of tTGA positive cases was significantly lower than tTGA negative ones (mean difference 7.17; 95% CI: 0.82-13.52). None of the tTGA positive T1DM patients had a history of chronic diarrhea, but one out of eight tTGA positives reported history of dermatitis (P = 0.001). Also, none of the tTGA positive subjects presented IgA deficiency. There was a significant difference in history of chronic diarrhea (P = 0.006) and autoimmune diseases (P = 0.001) between patients with T1DM and controls.

Conclusion: This study showed higher prevalence of CD in patients with T1DM than in general population of northwest Iran and the data lend support to recommend regular screening for CD in all patients with T1DM.

Keywords: Celiac disease; tissue transglutaminase antibodies; type 1 diabetes.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Tissue trnsglutaminase antibodies (tTGA) in patients with type 1 diabetes and controls
See this image and copyright information in PMC

References

    1. Atkinson MA, Eisenbarth GS. Type 1 diabetes: New perspectives on disease pathogenesis and treatment. Lancet. 2001;358:221–9. - PubMed
    1. Ciclitira PJ, Moodie SJ. Transition of care between paediatric and adult gastroenterology: Coeliac disease. Best Pract Res Clin Gastroenterol. 2003;17:181–95. - PubMed
    1. Rewers M. Epidemiology of celiac disease: What are the prevalence, incidence and progression of celiac disease? Gastroenterology. 2005;128:S47–51. - PubMed
    1. Payne WW. Coeliac disease and diabetes mellitus in the same patients. Great Ormond St J. 1954;8:118–22. - PubMed
    1. Farrel R, Kelly CP. Celiac sprue. N Engl J Med. 2002;346:180–8. - PubMed

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