doi: 10.1007/s10517-009-0624-x.
Interaction of afobazole with sigma1-receptors
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- PMID: 19902093
- DOI: 10.1007/s10517-009-0624-x
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Interaction of afobazole with sigma1-receptors
Bull Exp Biol Med.
2009 Jul.
Abstract
In vitro radioligand assay revealed interaction of afobazole with sigma(1)-receptors (Ki=5.9x10(-6) M). Translocation of sigma(1)-receptors from the endoplasmic reticulum to the outer membrane was demonstrated by confocal microscopy. Experiments were performed on the model of HT-22 immortalized hippocampal cells after incubation with afobazole in a concentration of 10(-8) M.
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