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. 2009 Jul;148(1):42-4.
doi: 10.1007/s10517-009-0624-x.

Interaction of afobazole with sigma1-receptors

S B Seredenin  1 , T A Antipova, M V Voronin, S Yu Kurchashova, A N Kuimov
Affiliations

Interaction of afobazole with sigma1-receptors

S B Seredenin et al. Bull Exp Biol Med. 2009 Jul.

Abstract

In vitro radioligand assay revealed interaction of afobazole with sigma(1)-receptors (Ki=5.9x10(-6) M). Translocation of sigma(1)-receptors from the endoplasmic reticulum to the outer membrane was demonstrated by confocal microscopy. Experiments were performed on the model of HT-22 immortalized hippocampal cells after incubation with afobazole in a concentration of 10(-8) M.

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