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. 2010 Aug;32(8):977-83.
doi: 10.1002/hed.21278.

Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients

Giorgio Peretti  1 , Cesare Piazza, Daniela Cocco, Luigi De Benedetto, Francesca Del Bon, Luca Oscar Redaelli De Zinis, Piero Nicolai
Affiliations

Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients

Giorgio Peretti et al. Head Neck. 2010 Aug.

Abstract

Background: Transoral CO(2) laser surgery has been accepted as a valuable therapeutic option for glottic cancer.

Methods: This was a retrospective analysis of 595 patients. Five-year overall and disease-specific survivals, local control with laser, locoregional, regional control, and organ preservation rates were calculated. The impact of different variables was calculated by univariate analysis.

Results: Overall, disease-specific and disease-free survivals, local control with laser, locoregional, regional control, and organ preservation rates were 87.5%, 99%, 81.3%, 92.7%, 98.9%, 98.2%, and 97.1%, respectively. Univariate analysis showed a significant impact of pT category on local control with laser, organ preservation, locoregional and regional control, of endoscopic re-treatment for positive deep surgical margins on local control with laser and organ preservation, and recurrence after endoscopic re-treatment on local control with laser and organ preservation.

Conclusion: This series confirms the good oncologic outcomes of endoscopic laser surgery for T(is), T(1), and selected T(2) and T(3) glottic tumors.

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