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Randomized Controlled Trial
. 2009 Oct;27(5):619-31.
doi: 10.3329/jhpn.v27i5.3638.

Effect of prenatal zinc supplementation on birthweight

Mahama Saaka  1 , Jacques Oosthuizen, Shelley Beatty
Affiliations
Randomized Controlled Trial

Effect of prenatal zinc supplementation on birthweight

Mahama Saaka et al. J Health Popul Nutr. 2009 Oct.

Abstract

Although iron and zinc deficiencies are known to occur together and also appear to be high in Ghana, a few supplementation studies addressed this concurrently in pregnancy. In a double-blind, randomized controlled trial, 600 pregnant women in Ghana were randomly assigned to receive either a combined supplement of 40 mg of zinc as zinc gluconate and 40 mg of iron as ferrous sulphate or 40 mg of elemental iron as ferrous sulphate. Overall, there was no detectable difference in the mean birthweight between the study groups, although the effect of iron-zinc supplementation on the mean birthweight was masked by a strong interaction between the type of supplement and the iron status of participants [F (1,179) = 5.614, p = 0.019]. Prenatal iron-zinc supplementation was effective in increasing the mean birthweight among anaemic and iron-deficient women but not among women with elevated iron stores in early pregnancy.

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Figures

Fig.
Fig.
A flow diagram showing the number of participants recruited, randomized, and lost-to-follow-up
See this image and copyright information in PMC

References

    1. Ghana. Wa: Ghana Health Service-Upper West Region; 2004. Upper West Regional Health Directorate. Annual report; p. 73.
    1. Arifeen SE, Black RE, Caulfield LE, Antelman G, Baqui AH, Nahar Q, et al. Infant growth patterns in the slums of Dhaka in relation to birth weight, intrauterine growth retardation, and prematurity. Am J Clin Nutr. 2000;72:1010–7. - PubMed
    1. Kalanda BF, van Buuren S, Verhoeff FH, Brabin BJ. Catch-up growth in Malawian babies, a longitudinal study of normal and low birthweight babies born in a malarious endemic area. Early Hum Dev. 2005;81:841–50. - PubMed
    1. Motta MEFA, da Silva GAP, Araújo OC, Lirai PI. Marília de Carvalho Lima. Does birth weight affect nutritional status at the end of first year of life? J Pediatr. 2005;81:377–82. - PubMed
    1. Olinto MT, Victora CG, Barros FC, Tomasi E. Determinants of malnutrition in a low-income population: hierarchical analytical model. Cad Saude Publ. 1993;9(Suppl 1):S14–27. - PubMed

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