doi: 10.1021/ol902365n.
Convergent synthesis of fostriecin via selective alkene couplings and regioselective asymmetric dihydroxylation
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- PMID: 19902969
- DOI: 10.1021/ol902365n
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Convergent synthesis of fostriecin via selective alkene couplings and regioselective asymmetric dihydroxylation
Org Lett.
.
Abstract
A highly convergent synthesis of fostriecin is described, featuring sequential palladium-catalyzed Negishi cross couplings to form the C7-C8 bond and C8-methyl bond, followed by late-stage regio- and stereoselective dihydroxylation of C8-C9.
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