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. 2009 Dec 3;11(23):5498-501.
doi: 10.1021/ol902365n.

Convergent synthesis of fostriecin via selective alkene couplings and regioselective asymmetric dihydroxylation

Omar Robles  1 , Frank E McDonald
Affiliations

Convergent synthesis of fostriecin via selective alkene couplings and regioselective asymmetric dihydroxylation

Omar Robles et al. Org Lett. .

Abstract

A highly convergent synthesis of fostriecin is described, featuring sequential palladium-catalyzed Negishi cross couplings to form the C7-C8 bond and C8-methyl bond, followed by late-stage regio- and stereoselective dihydroxylation of C8-C9.

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