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Review
. 2009 Nov;9(11):1615-21.
doi: 10.1586/ern.09.86.

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

Hyun-Pil Lee  1 , Gemma Casadesus, Xiongwei Zhu, Hyoung-gon Lee, George Perry, Mark A Smith, Katarzyna Gustaw-Rothenberg, Alan Lerner
Affiliations
Review

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

Hyun-Pil Lee et al. Expert Rev Neurother. 2009 Nov.

Abstract

Retinoic acid, an essential factor derived from vitamin A, has been shown to have a variety of functions including roles as an antioxidant and in cellular differentiation. Since oxidative stress and dedifferentiation of neurons appear to be common pathological elements of a number of neurodegenerative disorders, we speculated that retinoic acid may offer therapeutic promise. In this vein, recent compelling evidence indicates a role of retinoic acid in cognitive activities and anti-amyloidogenic properties. Here, we review the actions of retinoic acid that indicate that it may have therapeutic properties ideally served for the treatment of neurodegenerative diseases such as Alzheimer's disease.

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References

    1. Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 2007;21:1113–1124. - PMC - PubMed
    1. Reynolds CP, Matthay KK, Villablanca JG, Maurer BJ. Retinoid therapy of high-risk neuroblastoma. Cancer Lett. 2003;197:185–192. - PubMed
    1. Le Doze F, Debruyne D, Albessard F, Barre L, Defer GL. Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of Rat. Drug Metab Dispos. 2000;28:205–208. - PubMed
    1. Veal GJ, Errington J, Redfern CP, Pearson AD, Boddy AV. Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells. Biochem Pharmacol. 2002;63:207–215. - PubMed
    1. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell. 1995;83:841–850. - PubMed

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