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Review
. 2009 Nov;9(11):1615-21.
doi: 10.1586/ern.09.86.

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

Hyun-Pil Lee  1 , Gemma Casadesus, Xiongwei Zhu, Hyoung-gon Lee, George Perry, Mark A Smith, Katarzyna Gustaw-Rothenberg, Alan Lerner
Affiliations
Review

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

Hyun-Pil Lee et al. Expert Rev Neurother. 2009 Nov.

Abstract

Retinoic acid, an essential factor derived from vitamin A, has been shown to have a variety of functions including roles as an antioxidant and in cellular differentiation. Since oxidative stress and dedifferentiation of neurons appear to be common pathological elements of a number of neurodegenerative disorders, we speculated that retinoic acid may offer therapeutic promise. In this vein, recent compelling evidence indicates a role of retinoic acid in cognitive activities and anti-amyloidogenic properties. Here, we review the actions of retinoic acid that indicate that it may have therapeutic properties ideally served for the treatment of neurodegenerative diseases such as Alzheimer's disease.

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