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Review
. 2009 Nov;5(9):1449-75.
doi: 10.2217/fon.09.97.

Molecular and cellular biology of rhabdomyosarcoma

Carla De Giovanni  1 , Lorena Landuzzi, Giordano Nicoletti, Pier-Luigi Lollini, Patrizia Nanni
Affiliations
Review

Molecular and cellular biology of rhabdomyosarcoma

Carla De Giovanni et al. Future Oncol. 2009 Nov.

Abstract

Rhabdomyosarcoma is a group of soft-tissue sarcomas that share features of skeletal myogenesis, but show extensive heterogeneity in histology, age and site of onset, and prognosis. This review matches recent molecular data with biological features of rhabdomyosarcoma. Alterations in molecular pathways, animal models, cell of origin and potential new therapeutic targets are discussed.

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