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Review
. 2009 Dec;11(6):433-41.
doi: 10.1007/s11894-009-0067-6.

Gastric acid hypersecretory states: recent insights and advances

Nauramy Osefo  1 , Tetsuhide Ito, Robert T Jensen
Affiliations
Review

Gastric acid hypersecretory states: recent insights and advances

Nauramy Osefo et al. Curr Gastroenterol Rep. 2009 Dec.

Abstract

Gastric acid hypersecretory states are characterized by basal hypersecretion of gastric acid and historically include disorders associated with hypergastrinemia, hyperhistaminemia, and those of unknown etiology. Although gastric acid secretion is infrequently measured, it is important to recognize the role of gastric hypersecretion in the symptoms of these disorders because they share several features of pathogenesis and treatment. In this article, recent important articles reporting insights into their diagnosis, pathogenesis, and treatment are reviewed. Particular attention is paid to Zollinger-Ellison syndrome, because it has the most extreme acid hypersecretion of this group of disorders and because numerous recent articles deal with various aspects of the diagnosis, molecular pathogenesis, and treatment of the gastrinoma itself or the acid hypersecretion. Two new hypersecretory disorders are reviewed: rebound acid hypersecretion after the use of proton pump inhibitors and acid hypersecretion with cysteamine treatment in children with cystinosis.

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References

    1. Schubert ML, Peura DA. Control of gastric acid secretion in health and disease. Gastroenterology. 2008;134:1842–1860. - PubMed

    2. Comprehensive up-to-date review of the cellular, physiological and pathophysiological mechanisms involved in control of gastric acid secretion in both normals and in pathologic states.

    1. Roy P, Venzon DJ, Feigenbaum KM, et al. Gastric secretion in Zollinger-Ellison syndrome: correlation with clinical expression, tumor extent and role in diagnosis - A prospective NIH study of 235 patients and review of the literature in 984 cases. Medicine(Baltimore) 2001;80:189–222. - PubMed

    2. Detailed comprehensive analysis of the extent of gastric acid hypersecretion in patients with Zollinger-Ellison syndrome and its correlation with clinical, laboratory and tumoral features involving all patients prospectively studied at NIH as well as those reported in the literature. Only study to statistically analyze different proposed secretory criteria for ZES and to develop new ones that are clinically useful and supported by a detailed analysis of many patients.

    1. Jensen RT, Gardner JD. Gastrinoma. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA, editors. The Pancreas: Biology, Pathobiology and Disease. edn 2 Raven Press Publishing Co.; New York: 1993. pp. 931–978.
    1. Roy P, Venzon DJ, Shojamanesh H, et al. Zollinger-Ellison syndrome: clinical presentation in 261 patients. Medicine (Baltimore) 2000;79:379–411. - PubMed
    1. Nieto JM, Pisegna JR. The role of proton pump inhibitors in the treatment of Zollinger-Ellison syndrome. Expert Opin Pharmacother. 2006;7:169–175. - PubMed

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