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. 2009 Nov 15;15(22):6748-50.
doi: 10.1158/1078-0432.CCR-09-2305. Epub 2009 Nov 10.

Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?

Andrea P Myers  1 , Jeffrey A Meyerhardt, Lewis C Cantley
Affiliations

Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?

Andrea P Myers et al. Clin Cancer Res. .

Abstract

There is high morbidity associated with local recurrence of rectal cancer. However, the adjuvant therapies given to prevent such recurrences also have significant side effects and associated risks. The ability to select patients with the highest risk of recurrence and greatest therapeutic response will improve rectal cancer care.

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Figures

Fig. 1
Fig. 1
A schematic of receptor tyrosine kinase (RTK) activation of the PI3K and RAS-ERK pathways. The molecules in red demarcate the targets of drugs in early stage clinical trials. Studies in the preclinical arena suggest that single agent treatment with targeted drugs may be of utility in small genetic subsets. However, because of redundancy, negative feedback loops, and the genetic complexity of most tumors, these drugs may need to be used in combinations for their ultimate clinical success (9).
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