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Comparative Study
. 2010 Jan 5;102(1):42-7.
doi: 10.1038/sj.bjc.6605421. Epub 2009 Nov 10.

Age of onset in familial breast cancer as background data for medical surveillance

A Brandt  1 , J Lorenzo Bermejo, J Sundquist, K Hemminki
Affiliations
Comparative Study

Age of onset in familial breast cancer as background data for medical surveillance

A Brandt et al. Br J Cancer. .

Abstract

Background: Familial breast cancers are known to be of early onset. This article provides differences in the age of onset of breast cancer and death by breast cancer between women with and without a family history.

Methods: The Swedish Family-Cancer Database was used to estimate the cumulative risk of breast cancer and death by breast cancer according to family history with a stratified Cox model. Family history was defined separately for affected mother or sister considering their diagnostic ages.

Results: The age to reach the same cumulative incidence as women without family history decreased with decreasing diagnostic age of the affected relative. Women with a maternal history reached the risk of women lacking a family history at the age of 50 years between 12.3 (mother affected <40 years) and 3.3 years (mother affected >82 years) earlier. The trend for breast cancer mortality was essentially similar.

Conclusions: Women with mother or sister affected by breast cancer are diagnosed and die at earlier ages than do women without family history. The differences depend on the diagnostic age of the affected relative. The present data may provide a rationale to derive recommendations for the starting age of screening in women with affected family members.

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Figures

Figure 1
Figure 1
Cumulative incidence of breast cancer and cumulative risk of death by breast cancer according to the type of family history. (A) Age at which women with a family history reach the cumulative risk of women lacking a family history at the age of 40 and 50 years for incidence. (B) Age at which women with a family history reach the cumulative risk of women lacking a family history at the age of 40 and 50 years for death from breast cancer.
See this image and copyright information in PMC

References

    1. Advisory Committee on Cancer Prevention (2000) Recommendations on cancer screening in the European union. Eur J Cancer 36: 1473–1478 - PubMed
    1. Albert US, Schulz KD (2004) Short version of the Guideline: Early Detection of Breast Cancer in Germany. An evidence-, consensus-, and outcome-based guideline according to the German Association of the Scientific Medical Societies (AWMF) and the German Agency for Quality in Medicine (AeZQ). J Cancer Res Clin Oncol 130: 527–536 - PubMed
    1. Antoniou AC, Pharoah PP, Smith P, Easton DF (2004) The BOADICEA model of genetic susceptibility to breast and ovarian cancer. Br J Cancer 91: 1580–1590 - PMC - PubMed
    1. Bermejo JL, Hemminki K (2005) Familial risk of cancer shortly after diagnosis of the first familial tumor. J Natl Cancer Inst 97: 1575–1579 - PubMed
    1. Centre for Epidemiology (2005) Cancer Incidence in Sweden 2004. The National Board of Health and Welfare: Stockholm http://www.socialstyrelsen.se/Lists/Artikelkatalog/Attachments/10209/200..., Accessed 16 September 2009

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