Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2010 May;26(5):669-74.
doi: 10.1007/s00381-009-1025-1. Epub 2009 Nov 11.

Treatment of cystic craniopharyngioma with phosphorus-32 intracavitary irradiation

Rong Zhao  1 , Jinglan Deng, Xiaoyan Liang, Jin Zeng, Xiaoyuan Chen, Jing Wang
Affiliations
Clinical Trial

Treatment of cystic craniopharyngioma with phosphorus-32 intracavitary irradiation

Rong Zhao et al. Childs Nerv Syst. 2010 May.

Abstract

Purpose: The aim of the study was to evaluate the effect of phosphorus-32 colloid ([(32)P]) intracavitary irradiation on the treatment of patients with cystic craniopharyngiomas.

Methods: Twenty patients with predominantly cystic craniopharyngiomas were admitted from 1981 to 2006. Eleven patients had [(32)P] intracavitary irradiation by stereotactic injection or Ommaya cyst instillation as the primary treatment, and the remaining nine had the same internal irradiation as an adjuvant treatment after tumor resection. A calculated irradiation dose of 400 approximately 500 Gy per once was delivered to the cyst wall.

Conclusion: The patients were followed up ranging from 36 to 336 months; no operative morbidity or mortality was found from [(32)P] intracavitary irradiation. Fourteen patients (70%) had tumor progression and required further two to four times intracavitary irradiation. All 20 cases achieved tumor shrinkage or stabilization with effective outcome 3-6 months after the last [(32)P] therapy. For patients with cystic craniopharyngioma, [(32)P] administration by stereotactic injection or Ommaya cyst instillation is a safe and helpful option, which could improve the life quality, prolong the life span, and enhance the survival rate of cystic craniopharyngioma patients.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Pattern of Ommaya reservoir system
Fig. 2
Fig. 2
Case 2: MRI of cystic craniopharyngioma in a 5-year-old boy before (a cyst diameter≈3.8 cm) and after (b cyst diameter≈1.2 cm) [32P] treatment
Fig. 3
Fig. 3
Case 3: MRI of cystic craniopharyngioma in a 1.7-year-old boy before (a cyst diameter≈4.4 cm) and after (b cyst diameter≈1.5 cm) [32P] treatment
Fig. 4
Fig. 4
Case 2: The bremsstrahlung scanning of cystic craniopharyngioma in a 5-year-old boy treated with intracavitary [32P] in intervals up to the third day of postinstillation: It is never presented the bremsstrahlung image outside the target cyst
See this image and copyright information in PMC

References

    1. Karavitaki N, Cudlip S, Adams CBT, Wass JAH. Craniopharyngiomas. Endo Rev. 2006;27:371–397. - PubMed
    1. Dekkers OM, Biermasz NR, Smit JWA, Groot LE, Roelfsema F, Romijn JA, Pereira AM. Quality of life in treated adult craniopharyngioma patients. Eur Journal of Endocrinol. 2006;154:483–489. - PubMed
    1. Leksell L, Liden K. 32P radiation in the treatment of craniopharyngiomas. J Neurooncol. 1952;56:69–78.
    1. Richmond IL, Wara WM, Wilson CB. Role of radiation therapy in the management of craniopharyngiomas in children. Neurosurgery. 1980;6:513–517. - PubMed
    1. Kobayashi T, Kageyama N, Ohara K. Internal irradiation for cystic craniopharyngioma. J Neurosurg. 1981;55:896–903. - PubMed

Publication types

Substances