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Review
. 2009 Nov;67(11):615-23.
doi: 10.1111/j.1753-4887.2009.00246.x.

Choline: an essential nutrient for public health

Steven H Zeisel  1 , Kerry-Ann da Costa
Affiliations
Review

Choline: an essential nutrient for public health

Steven H Zeisel et al. Nutr Rev. 2009 Nov.

Abstract

Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998. There is significant variation in the dietary requirement for choline that can be explained by common genetic polymorphisms. Because of its wide-ranging roles in human metabolism, from cell structure to neurotransmitter synthesis, choline-deficiency is now thought to have an impact on diseases such as liver disease, atherosclerosis, and, possibly, neurological disorders. Choline is found in a wide variety of foods. Eggs and meats are rich sources of choline in the North American diet, providing up to 430 milligrams per 100 grams. Mean choline intakes for older children, men, women, and pregnant women are far below the adequate intake level established by the IOM. Given the importance of choline in a wide range of critical functions in the human body, coupled with less-than-optimal intakes among the population, dietary guidance should be developed to encourage the intake of choline-rich foods.

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Figures

Figure 1
Figure 1
Metabolic pathway of choline
See this image and copyright information in PMC

References

    1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B012, Pantothenic Acid, Biotin, and Choline. Washington, D.C.: National Academy of Sciences; 1998. pp. 390–422.
    1. Penry J, Manore M. Choline: an important micronutirent for maximal endurance-exercise performance? Int J Sport Nutr Exerc Metab. 2008;18:191–203. - PubMed
    1. Stead L, Brosnan J, Brosnan M, Vance D, Jacobs R. Is it time to reevaluate methyl balance in humans. Am J Clin Nutr. 2006;83:5–10. - PubMed
    1. Zeisel S. Choline, an essential nutrient for humans. FASEB. 1991;5:2093–2098. - PubMed
    1. Shaw G, Carmichael S, Yang W, Selvin S, Schaffer D. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol. 2004;160:102–109. - PubMed

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