A randomized, double-blind study examining the comparative efficacies and safety of inhaled epinephrine and nasal decongestant in hospitalized infants with acute bronchiolitis
- PMID: 19907355
- DOI: 10.1097/INF.0b013e3181b0602e
A randomized, double-blind study examining the comparative efficacies and safety of inhaled epinephrine and nasal decongestant in hospitalized infants with acute bronchiolitis
Abstract
Optimal treatment of acute bronchiolitis is currently unclear. In a double-blind study, we found no significant differences between inhaled epinephrine and nasal decongestant in hospitalized infants with acute bronchiolitis regarding length of hospitalization, need for oxygen supplementation, or intravenous fluids and clinical score. Nasal decongestant is as effective as inhaled epinephrine in acute bronchiolitis.
Trial registration: ClinicalTrials.gov NCT00622817.
Similar articles
-
A multicenter, randomized, double-blind, controlled trial of nebulized epinephrine in infants with acute bronchiolitis.N Engl J Med. 2003 Jul 3;349(1):27-35. doi: 10.1056/NEJMoa022226. N Engl J Med. 2003. PMID: 12840089 Clinical Trial.
-
Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076].BMC Pediatr. 2005 May 5;5(1):7. doi: 10.1186/1471-2431-5-7. BMC Pediatr. 2005. PMID: 15876347 Free PMC article. Clinical Trial.
-
High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis.Pediatr Pulmonol. 2010 Jan;45(1):41-7. doi: 10.1002/ppul.21108. Pediatr Pulmonol. 2010. PMID: 19953579 Clinical Trial.
-
Does nebulised adrenaline reduce admission rate in bronchiolitis?Arch Dis Child. 2001 Sep;85(3):254-255. Arch Dis Child. 2001. PMID: 12035815 Review. No abstract available.
-
[ Pediatric patients with bronchiolitis or obstructive bronchitis].Duodecim. 1996;112(24):2375-82. Duodecim. 1996. PMID: 10605238 Review. Finnish. No abstract available.
Cited by
-
Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial.Indian J Pediatr. 2015 Sep;82(9):794-8. doi: 10.1007/s12098-015-1729-z. Epub 2015 Mar 4. Indian J Pediatr. 2015. PMID: 25731897 Clinical Trial.
-
Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins.ACS Med Chem Lett. 2020 Apr 10;11(6):1145-1151. doi: 10.1021/acsmedchemlett.0c00008. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32550994 Free PMC article.
-
Safety and efficacy of phenylephrine nasal drops in bronchiolitis.Iran J Pediatr. 2014 Oct;24(5):593-7. Epub 2014 Oct 5. Iran J Pediatr. 2014. PMID: 25793067 Free PMC article.
-
Scientific rationale for the use of alpha-adrenergic agonists and glucocorticoids in the therapy of pediatric stridor.Int J Otolaryngol. 2011;2011:575018. doi: 10.1155/2011/575018. Epub 2011 Dec 19. Int J Otolaryngol. 2011. PMID: 22220172 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
LinkOut - more resources
Full Text Sources
Medical