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. 2009 May;147(5):570-2.
doi: 10.1007/s10517-009-0580-5.

Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia

[Article in English, Russian]
V V Moroz  1 , A B Salmina, A A Fursov, S V Mikhutkina, K Y Linev, N S Mantorova, S V Shakhmaeva
Affiliations

Role of ADP-ribosyl cyclase in the pathogenesis of neurological disorders after coronary artery bypass surgery and experimental ischemia

[Article in English, Russian]
V V Moroz et al. Bull Exp Biol Med. 2009 May.

Abstract

The pathogenesis of neuronal dysfunction was evaluated from the viewpoint of cellular disturbances in NAD(+) metabolism and changes in activity of NAD(+)-utilizing enzymes (e.g., ADP-ribosyl cyclase/CD38). S-100B concentration and CD38 expression on peripheral blood lymphocytes were altered in patients after surgery for coronary heart disease with extracorporeal circulation. These changes in patients during the early postoperative period correlated with variations in CD38 expression on neuronal cells from postischemic rats with cognitive dysfunction.

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