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. 2009 Nov 14;15(42):5274-8.
doi: 10.3748/wjg.15.5274.

Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans

M Mazen Jamal  1 , Eugene J Yoon, Kenneth J Vega, Mehrtash Hashemzadeh, Kenneth J Chang
Affiliations

Diabetes mellitus as a risk factor for gastrointestinal cancer among American veterans

M Mazen Jamal et al. World J Gastroenterol. .

Abstract

Aim: To assess the risk of biliary and pancreatic cancers in a large cohort of patients with type 2 diabetes mellitus (DM).

Methods: Eligibility for this study included patients with type 2 DM (ICD-9 code 250.0) who were discharged from Department of Veteran Affairs hospitals between 1990 and 2000. Non-matched control patients without DM were selected from the same patient treatment files during the same period. Demographic information included age, sex and race. Secondary diagnoses included known risk factors based on their ICD-9 codes. By multivariate logistic regression, the occurrence of biliary and pancreatic cancer was compared between case subjects with DM and controls without DM.

Results: A total of 1,172,496 case and control subjects were analyzed. The mean age for study and control subjects was 65.8+/-11.3 and 64.8+/-12.6 years, respectively. The frequency of pancreatic cancer in subjects with DM was increased (0.9%) in comparison to control subjects (0.3%) with an OR of 3.22 (95% CI: 3.03-3.42). The incidence of gallbladder and extrahepatic biliary cancers was increased by twofold in diabetic patients when compared to controls. The OR and 95% CI were 2.20 (1.56-3.00) and 2.10 (1.61-2.53), respectively.

Conclusion: Our study demonstrated that patients with DM have a threefold increased risk for developing pancreatic cancer and a twofold risk for developing biliary cancer.

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References

    1. Støvring H, Andersen M, Beck-Nielsen H, Green A, Vach W. Rising prevalence of diabetes: evidence from a Danish pharmaco-epidemiological database. Lancet. 2003;362:537–538. - PubMed
    1. Chauhan TS. Diabetes' rising toll. CMAJ. 2003;169:1068. - PMC - PubMed
    1. Hassan MM, Hwang LY, Hatten CJ, Swaim M, Li D, Abbruzzese JL, Beasley P, Patt YZ. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. Hepatology. 2002;36:1206–1213. - PubMed
    1. Wideroff L, Gridley G, Mellemkjaer L, Chow WH, Linet M, Keehn S, Borch-Johnsen K, Olsen JH. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst. 1997;89:1360–1365. - PubMed
    1. El-Serag HB, Richardson PA, Everhart JE. The role of diabetes in hepatocellular carcinoma: a case-control study among United States Veterans. Am J Gastroenterol. 2001;96:2462–2467. - PubMed