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Comparative Study
. 2009 Nov 12:2:47.
doi: 10.1186/1756-8722-2-47.

Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma

Chung-Che Chang  1 , Xiaobo Zhou, Jesalyn J Taylor, Wan-Ting Huang, Xianwen Ren, Federico Monzon, Yongdong Feng, Pulivarthi H Rao, Xin-Yan Lu, Facchetti Fabio, Susan Hilsenbeck, Chad J Creighton, Elaine S Jaffe, Ching-Ching Lau
Affiliations
Comparative Study

Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma

Chung-Che Chang et al. J Hematol Oncol. .

Abstract

Background: Plasmablastic lymphoma (PL) is a subtype of diffuse large B-cell lymphoma (DLBCL). Studies have suggested that tumors with PL morphology represent a group of neoplasms with clinopathologic characteristics corresponding to different entities including extramedullary plasmablastic tumors associated with plasma cell myeloma (PCM). The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization.

Results: Examination of genomic data in PL revealed that the most frequent segmental gain (> 40%) include: 1p36.11-1p36.33, 1p34.1-1p36.13, 1q21.1-1q23.1, 7q11.2-7q11.23, 11q12-11q13.2 and 22q12.2-22q13.3. This correlated with segmental gains occurring in high frequency in DLBCL (AIDS-related and non AIDS-related) cases. There were some segmental gains and some segmental loss that occurred in PL but not in the other types of lymphoma suggesting that these foci may contain genes responsible for the differentiation of this lymphoma. Additionally, some segmental gains and some segmental loss occurred only in PL and AIDS associated DLBCL suggesting that these foci may be associated with HIV infection. Furthermore, some segmental gains and some segmental loss occurred only in PL and PCM suggesting that these lesions may be related to plasmacytic differentiation.

Conclusion: To the best of our knowledge, the current study represents the first genomic exploration of PL. The genomic aberration pattern of PL appears to be more similar to that of DLBCL (AIDS-related or non AIDS-related) than to PCM. Our findings suggest that PL may remain best classified as a subtype of DLBCL at least at the genome level.

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Figures

Figure 1
Figure 1
Plasmablastic lymphoma (PL) is more similar to diffuse large B-cell lymphoma (DLBCL) and AIDS-related DLBCL (AIDS-DLBCL) than plasma cell myeloma (PCM). A. Upper panel: The heatmap of genomic lesions by array CGH among 4 groups of lymphoma studied. The left column shows the number of chromosomes. The right column shows the frequencies of gains (represented by positive values) or loss (represented by negative values). Lower panel: The Pearson correlation coefficient among different groups of lymphomas. B. FISH validation of gains of 16p13.3 frequently identified in PL cases by array CGH. Shown is the interphase cells hybridized with RP11-88L24 (2q31.2/Red) as control and RP11-417B20 (16p31.2/Green) in a representative case. A magnified image of an interphase cell showing three copies of RP11-417B20 and two copies of RP11-88L24 is shown as an inset.
See this image and copyright information in PMC

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