Multiple system atrophy: an update
- PMID: 19909915
- DOI: 10.1016/S1474-4422(09)70288-1
Multiple system atrophy: an update
Abstract
Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with parkinsonism or cerebellar ataxia. Over the past 5 years, substantial progress has been achieved in understanding the pathogenesis of the disease. Important insights into the epidemiology and genetics of MSA have confirmed the key pathogenic role of alpha-synuclein. Advances in the early recognition of this disease have resulted in revised diagnostic criteria, including, for the first time, neuroimaging indices. Finally, novel therapeutic options targeting disease modification have been investigated in clinical trials. These include riluzole, recombinant human growth hormone, and minocycline. Although the trials did not find any positive effects on disease progression, they generated important trial expertise in MSA and were only possible because of the establishment of international networks.
Similar articles
-
Multiple system atrophy.Handb Clin Neurol. 2013;117:229-41. doi: 10.1016/B978-0-444-53491-0.00019-5. Handb Clin Neurol. 2013. PMID: 24095129 Review.
-
[Towards more efficient clinical trials for multiple system atrophy in Japan].Brain Nerve. 2012 Oct;64(10):1141-9. Brain Nerve. 2012. PMID: 23037604 Review. Japanese.
-
Multiple system atrophy: an update.Mov Disord. 2003 Sep;18 Suppl 6:S34-42. doi: 10.1002/mds.10561. Mov Disord. 2003. PMID: 14502654
-
Multiple system atrophy of the cerebellar type: clinical state of the art.Mov Disord. 2014 Mar;29(3):294-304. doi: 10.1002/mds.25847. Epub 2014 Feb 24. Mov Disord. 2014. PMID: 24615754 Review.
-
Grading of neuropathology in multiple system atrophy: proposal for a novel scale.Mov Disord. 2005 Aug;20 Suppl 12:S29-36. doi: 10.1002/mds.20537. Mov Disord. 2005. PMID: 16092088
Cited by
-
Prevalence and impact of sleep-related breathing disorder in multiple system atrophy patients: a cross-sectional study and meta-analysis.Front Neurol. 2024 Aug 20;15:1440932. doi: 10.3389/fneur.2024.1440932. eCollection 2024. Front Neurol. 2024. PMID: 39228511 Free PMC article.
-
Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein.Sci Rep. 2015 May 18;5:9862. doi: 10.1038/srep09862. Sci Rep. 2015. PMID: 25985292 Free PMC article.
-
Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline).Clin Sci (Lond). 2015 Jul;129(2):107-16. doi: 10.1042/CS20140766. Clin Sci (Lond). 2015. PMID: 25706983 Free PMC article.
-
Pregnancy in multiple system atrophy: a case report.J Med Case Rep. 2011 Dec 30;5:599. doi: 10.1186/1752-1947-5-599. J Med Case Rep. 2011. PMID: 22208291 Free PMC article.
-
Structural and Functional Brain Mapping Correlates of Impaired Eye Movement Control in Parkinsonian Syndromes: A Systems-Based Concept.Front Neurol. 2018 May 7;9:319. doi: 10.3389/fneur.2018.00319. eCollection 2018. Front Neurol. 2018. PMID: 29867729 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous