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. 2009 Dec 17;11(24):5714-6.
doi: 10.1021/ol902507x.

Highly enantioselective ketone-ene reactions of trifluoropyruvate: significant counterion effect of the In(III)-pybox complex

Jun-Feng Zhao  1 , Teguh-Budiono W Tjan, Boon-Hong Tan, Teck-Peng Loh
Affiliations

Highly enantioselective ketone-ene reactions of trifluoropyruvate: significant counterion effect of the In(III)-pybox complex

Jun-Feng Zhao et al. Org Lett. .

Abstract

A chiral indium(III)-pybox complex catalyzed asymmetric ketone-ene reaction of trifluoropyruvate is described. Both aromatic and aliphatic 1,1-disubstituted alkenes reacted smoothly to give the enantioenriched tertiary homoallylic alcohols in good to excellent yields (up to 99%) and with excellent enantioselectivities (up to 98% ee).

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