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Review
. 2010 Feb;159(2):148-58.
doi: 10.1111/j.1365-2249.2009.04041.x. Epub 2009 Nov 11.

Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells

E de Jong  1 , T Suddason, G M Lord
Affiliations
Review

Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells

E de Jong et al. Clin Exp Immunol. 2010 Feb.

Abstract

There has been a considerable amount of interest in the immunological community about new phenotypic subsets of CD4(+) T cells, particularly cells that produce the cytokine interleukin (IL)-17 [named T helper type 17 (Th17) cells]. While the initial discovery of Th17 cells and the pathways that controlled their development was in the mouse, recent attention has shifted to the existence of these cells and the relevant upstream cytokine signals in humans. While it is clear that CD4(+) T cells producing IL-17 exist in vivo, their relevance to disease pathogenesis is only just being understood. In this paper, we review the data regarding the generation of human Th17 cells in vitro and the evidence that this effector population is important in human disease states.

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Figures

Fig. 1
Fig. 1
Dendritic cells (DC) promote the development of distinct T helper cell subsets.
Fig. 2
Fig. 2
Development of murine interleukin (IL)-17 producing CD4+ T cells.
Fig. 3
Fig. 3
Production of interleukin (IL)-17 from naive versus memory T cells skewed towards T helper type 17 (Th17) conditions. Different skewing conditions are used for different cell types.
See this image and copyright information in PMC

References

    1. Kapsenberg ML. Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol. 2003;3:984–93. - PubMed
    1. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100:655–69. - PubMed
    1. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002;295:338–42. - PubMed
    1. Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997;89:587–96. - PubMed
    1. Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123–32. - PubMed

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