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Review
. 2010 Feb;159(2):131-6.
doi: 10.1111/j.1365-2249.2009.04039.x. Epub 2009 Nov 11.

Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?

M I Koenders  1 , W B van den Berg
Affiliations
Review

Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?

M I Koenders et al. Clin Exp Immunol. 2010 Feb.

Abstract

In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.

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Figures

Fig. 1
Fig. 1
T helper type 17 (Th17) formation from precursor Th0 cells and major products of Th17 cells.
See this image and copyright information in PMC

References

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