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. 1993 Aug;4(4):310-8.
doi: 10.1006/mcne.1993.1041.

Characterization of the brain family of aromatic amine N-acetyltransferases

S J Gaudet  1 , M A Namboodiri
Affiliations

Characterization of the brain family of aromatic amine N-acetyltransferases

S J Gaudet et al. Mol Cell Neurosci. 1993 Aug.

Abstract

Arylamine and arylalkylamine N-acetyltransferase activities in the rat brain were isolated and partially characterized. A total of four N -acetyltransferase activities were identified using a combination of three separation procedures, ammonium sulfate fractionation, methotrexate affinity chromatography, and size-exclusion HPLC. Two of the N -acetyltransferase activities demonstrated preference for arylamines and differential sensitivity to inhibition by methotrexate. The other two activities were characterized as arylalkylamine N-acetyltransferase based on their preference for arylalkylamines such as serotonin and tryptamine. Potential functions of these enzyme activities in the brain are discussed.

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