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Comment
. 2009 Nov 13;139(4):654-6.
doi: 10.1016/j.cell.2009.10.035.

Transformation locked in a loop

Jarno Drost  1 , Reuven Agami
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Free article
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Transformation locked in a loop

Jarno Drost et al. Cell. .
Free article

Abstract

During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transient oncogenic signal is sufficient to induce neoplastic transformation and to maintain it through a positive feedback loop driven by the inflammatory cytokine interleukin-6.

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