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Comment
. 2009 Dec;10(12):1229-31.
doi: 10.1038/ni1209-1229.

MicroRNA--managing the TH-17 inflammatory response

Aaron J Martin, Liang Zhou, Stephen D Miller
Comment

MicroRNA--managing the TH-17 inflammatory response

Aaron J Martin et al. Nat Immunol. 2009 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1. miR-326 encourages TH-17 cell differentiation
miR-326 is transcribed from non-coding regions of the β-arrestin gene. In the cytoplasm, miR-326 binds to a complimentary UTR in the 3’ region of the Ets-1 message and prevents translation of the message. This prevents Ets-1 protein from accumulating and interfering with TH-17 cell differentiation by way of IL-2 synthesis and signaling pathways. Interestingly, miR-326 was not found to target Foxp3 mRNA to perturb Foxp3 protein expression required for the inhibition of RORγt activity. Signaling events downstream of the IL-6R are still required to prevent TH-17 cell lineage antagonism by Foxp3. RORγt expression was upregulated by miR-326, suggesting that miR-326 may somehow enhance the expression of the TH-17 cell lineage transcription factor via interference with an unknown inhibitor of RORγt.
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