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. 2010 Feb;33(2):402-4.
doi: 10.2337/dc09-1393. Epub 2009 Nov 16.

Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children

Ghattu V Krishnaveni  1 , Sargoor R Veena, Jacqueline C Hill, Sarah Kehoe, Samuel C Karat, Caroline H D Fall
Affiliations

Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children

Ghattu V Krishnaveni et al. Diabetes Care. 2010 Feb.

Abstract

Objective: To test the hypothesis that maternal gestational diabetes increases cardiovascular risk markers in Indian children.

Research design and methods: Anthropometry, blood pressure, and glucose/insulin concentrations were measured in 514 children at 5 and 9.5 years of age (35 offspring of diabetic mothers [ODMs], 39 offspring of diabetic fathers [ODFs]). Children of nondiabetic parents were control subjects.

Results: At age 9.5 years, female ODMs had larger skinfolds (P < 0.001), higher glucose (30 min) and insulin concentrations, and higher homeostasis model assessment (HOMA) of insulin resistance and systolic blood pressure (P < 0.05) than control subjects. Male ODMs had higher HOMA (P < 0.01). Associations were stronger than at age 5 years. Female ODFs had larger skinfolds and male ODFs had higher HOMA (P < 0.05) than control subjects; associations were weaker than for ODMs. Associations between outcomes in control subjects and parental BMI, glucose, and insulin concentrations were similar for mothers and fathers.

Conclusions: The intrauterine environment experienced by ODMs increases diabetes and cardiovascular risk over genetic factors; the effects strengthen during childhood.

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References

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