Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009 Aug 7:2:6948.
doi: 10.4076/1757-1626-2-6948.

Primary mediastinal synovial sarcoma: a case report and review of the literature

Benjamin Henninger  1 , Martin Freund, Bettina Zelger, Daniel Putzer, Hugo Bonatti, Ludwig Müller, Michael Fiegl, Christian Geltner
Affiliations
Case Reports

Primary mediastinal synovial sarcoma: a case report and review of the literature

Benjamin Henninger et al. Cases J. .

Abstract

Primary mediastinal synovial sarcoma is a rare malignancy with only a few cases reported so far. A 56-year-old woman was admitted to our hospital for an investigation of a nodule in the left middle lung on chest radiography. Computed tomography revealed a mediastinal mass first described as a solitary fibrous tumor. The diagnosis of synovial sarcoma was established by computed tomography-guided percutaneous needle biopsy. Work up showed no metastasis to distant organs or contralateral pleural cavity. The mass was surgically resected; pathological and immunohistochemical analyses confirmed the diagnosis of a monophasic spindle cell synovial sarcoma probably originating from phrenic nerve. The patient received adjuvant chemotherapy and radiation and is free of recurrence after a follow up of 16 months.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Chest radiograph demonstrating a mass in the left middle field.
Figures 2 and 3.
Figures 2 and 3.
Chest computed tomography showed an 3 × 5 cm measuring intrathoracic tumor with broadly based contact to the pericardium, surrounded by pneumatocele. It was identified as an extrapulmonary, mediastinal benign solitary fibrous tumor.
Figures 2 and 3.
Figures 2 and 3.
Chest computed tomography showed an 3 × 5 cm measuring intrathoracic tumor with broadly based contact to the pericardium, surrounded by pneumatocele. It was identified as an extrapulmonary, mediastinal benign solitary fibrous tumor.
Figure 4.
Figure 4.
Chest computed tomography after resection of the tumor through a thoracotomy. This image shows volume reduction and fluid accumulation with no signs of relapse.
Figure 5.
Figure 5.
Dense cellular spindle cell proliferation with fascicular growth pattern and nuclear atypia. No glandular biphasic pattern. H&E, 100×.
Figure 6.
Figure 6.
Focally strong keratin positivity. Immunohistochemistry with Cam 5.2, 200×.
See this image and copyright information in PMC

References

    1. Adigun IA, Rahman GA. A review of soft tissue sarcoma. Niger J Med. 2007;16(2):94–101. - PubMed
    1. Cormier JN, Pollock RE. Soft tissue sarcomas. CA Cancer J Clin. 2004;54(2):94–109. doi: 10.3322/canjclin.54.2.94. - DOI - PubMed
    1. Fletcher CD. The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology. 2006;48(1):3–12. doi: 10.1111/j.1365-2559.2005.02284.x. - DOI - PubMed
    1. Spillane AJ, A’Hern R, Judson IR, Fisher C, Thomas JM. Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol. 2000;18(22):3794–3803. - PubMed
    1. Deshmukh R, Mankin HJ, Singer S. Synovial sarcoma: the importance of size and location for survival. Clin Orthop Relat Res. 2004;(419):155–161. doi: 10.1097/00003086-200402000-00025. - DOI - PubMed

Publication types

LinkOut - more resources