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Review
. 2009 Nov:Chapter 11:11.9D.1-11.9D.19.
doi: 10.1002/0471142735.im1109ds87.

TRAF-mediated TNFR-family signaling

Hyunil Ha  1 , Daehee Han  1 , Yongwon Choi  1
Affiliations
Review

TRAF-mediated TNFR-family signaling

Hyunil Ha et al. Curr Protoc Immunol. 2009 Nov.

Abstract

The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell-bound and secreted proteins that regulate numerous cellular processes. In particular, TNF-family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor-associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF-interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF-knockout mice.

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