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. 2009 Dec 18;74(24):9287-91.
doi: 10.1021/jo901924m.

Direct conversion of thiols to sulfonyl chlorides and sulfonamides

Kiumars Bahrami  1 , Mohammad M Khodaei, Mehdi Soheilizad
Affiliations

Direct conversion of thiols to sulfonyl chlorides and sulfonamides

Kiumars Bahrami et al. J Org Chem. .

Abstract

H(2)O(2) in combination with SOCl(2) proved to be a highly reactive reagent for the direct oxidative conversion of thiol derivatives to the corresponding sulfonyl chlorides with high purity through oxidative chlorination. Upon reaction with amines, the corresponding sulfonamides were obtained in excellent yields and in very short reaction times.

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