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. 2009 Dec;72(12):2115-9.
doi: 10.1021/np900654a.

Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum

Huijuan Guo  1 , Bingda Sun, Hao Gao, Xulin Chen, Shuchun Liu, Xinsheng Yao, Xingzhong Liu, Yongsheng Che
Affiliations

Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum

Huijuan Guo et al. J Nat Prod. 2009 Dec.

Erratum in

  • J Nat Prod. 2010 Apr 23;73(4):796
  • J Nat Prod. 2011 May 27;74(5):1351

Abstract

New diketopiperazines, epicoccins E-H (1-4) and diphenylalazines A (5) and B (6), have been isolated from the solid-substrate fermentation culture of the Cordyceps-colonizing fungus Epicoccum nigrum. The structures of 1-6 were determined primarily by NMR experiments, and the structure of 1 was confirmed by X-ray crystallography. The absolute configurations of 3 and 5 were assigned using the modified Mosher (3) and Marfey's (5) methods, respectively. Compounds 3-5 showed inhibitory effects on HIV-1 replication in C8166 cells.

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