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. 2009 Nov 25;131(46):16614-5.
doi: 10.1021/ja9061085.

Enzyme responsive nanocontainers with cyclodextrin gatekeepers and synergistic effects in release of guests

Chiyoung Park  1 , Hyehyeon Kim, Saehee Kim, Chulhee Kim
Affiliations

Enzyme responsive nanocontainers with cyclodextrin gatekeepers and synergistic effects in release of guests

Chiyoung Park et al. J Am Chem Soc. .

Abstract

The cyclodextrin covered porous silica nanoparticles (Si-MPs) exhibited enzyme responsive characteristics. The cyclodextrin gatekeepers on the surface of Si-MPs can be hydrolyzed by a-amylase to release guest molecules from the porous reservoir. The ester linkage in the stalk part of the cyclodextrin gatekeeper can also be cleaved by lipase to release guests from the channel. Our approach would provide a unique methodology for controlled delivery systems.

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