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. 2009 Dec 15;200(12):1901-6.
doi: 10.1086/648474.

Distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck

Elizabeth R Richter  1 , James K Dias, James E Gilbert 2nd, Sally S Atherton
Affiliations

Distribution of herpes simplex virus type 1 and varicella zoster virus in ganglia of the human head and neck

Elizabeth R Richter et al. J Infect Dis. .

Abstract

The distribution of the neurotropic alphaherpesviruses-herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) and varicella zoster virus (VZV)-was determined in autonomic and sensory ganglia of the head and neck obtained from formalin-fixed human cadavers. HSV-1 and VZV DNA were found in 18 of 58 and 16 of 58 trigeminal, 23 of 58 and 11 of 58 pterygopalatine, 25 of 60 and 14 of 60 ciliary, 25 of 48 and 11 of 48 geniculate, 15 of 50 and 8 of 50 otic, 14 of 47 and 4 of 47 submandibular, 18 of 58 and 10 of 58 superior cervical, and 12 of 36 and 1 of 36 nodose ganglia, respectively. HSV-2 was not detected at any site. Viral DNA positivity and location were independently distributed among autonomic and sensory ganglia of the human head and neck.

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References

    1. Kleinschmidt-DeMasters BK, Gilden DH. The expanding spectrum of herpesvirus infections of the nervous system. Brain Pathol. 2001;11:440–451. - PMC - PubMed
    1. Xu F, Sternberg MR, Kottiri BJ, et al. Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States. JAMA. 2006;296:964–973. - PubMed
    1. Jerant AF, DeGaetano JS, Epperly TD, Hannapel AC, Miller DR, Lloyd AJ. Varicella susceptibility and vaccination strategies in young adults. J Am Board Fam Pract. 1998;11:296–306. - PubMed
    1. Mitchell BM, Bloom DC, Cohrs RJ, Gilden DH, Kennedy PG. Herpes simplex virus-1 and varicella-zoster virus latency in ganglia. J Neurovirol. 2003;9:194–204. - PubMed
    1. Lafferty WE, Coombs RW, Benedetti J, Critchlow C, Corey L. Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type. N Engl J Med. 1987;316:1444–1449. - PubMed

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