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. 2009 Dec;14(12):1068-9.
doi: 10.1038/mp.2009.62.

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain

Y Marchalant, H M Brothers, G L Wenk
Free PMC article

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain

Y Marchalant et al. Mol Psychiatry. 2009 Dec.
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
(A) Doublecortin immunoreactivity (IR) in the dentate gyrus (DG). For all pictures, Doublecortin immunoreactivity (DCX-IR) is in green and NeuN-IR is in red. (a, b) 3-month-young rats, magnification × 600. (c, d) 23-month control rats, magnification × 600. (e, f) 23-month-old rats treated for 3 weeks with 2 mg kg−1 per day of WIN-55,212-2, magnification × 600. Note the significant decrease in DCX-IR between young (a, b) and aged control (c, d) rats, as well as the significant increase in DCX-IR between aged controls (c, d) and WIN-treated aged (e, f) rats. (B) Number of DCX-IR cells by DG: a significant increase (116%, *P<0.05, Fisher's PLSD post-hoc test) of doublecortin immunoreactive cells was observed in the subgranular zone of the dentate gyrus of rats treated 3 weeks with 2 mg kg−1 per day of WIN-55,212-2. (C) 5-bromo-2-deoxyuridine (BrdU)-positive cells in the DG of aged animals: a significant increase (63%, *P<0.05, Fisher's PLSD post-hoc test) of BrdU immunoreactive cells was observed in the subgranular zone of the dentate gyrus of rats treated for 3 weeks with 2 mg kg−1 per day of WIN-55,212-2. (D) Proportion of neurons/glia co-localized with BrdU cells in the DG of aged animals: no significant changes could be seen in the proportion of new neurons over new glial cells.
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