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. 2009 Dec;14(12):1068-9.
doi: 10.1038/mp.2009.62.

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain

Y Marchalant, H M Brothers, G L Wenk
Free PMC article

Cannabinoid agonist WIN-55,212-2 partially restores neurogenesis in the aged rat brain

Y Marchalant et al. Mol Psychiatry. 2009 Dec.
Free PMC article
No abstract available

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Figures

Figure 1
Figure 1
(A) Doublecortin immunoreactivity (IR) in the dentate gyrus (DG). For all pictures, Doublecortin immunoreactivity (DCX-IR) is in green and NeuN-IR is in red. (a, b) 3-month-young rats, magnification × 600. (c, d) 23-month control rats, magnification × 600. (e, f) 23-month-old rats treated for 3 weeks with 2 mg kg−1 per day of WIN-55,212-2, magnification × 600. Note the significant decrease in DCX-IR between young (a, b) and aged control (c, d) rats, as well as the significant increase in DCX-IR between aged controls (c, d) and WIN-treated aged (e, f) rats. (B) Number of DCX-IR cells by DG: a significant increase (116%, *P<0.05, Fisher's PLSD post-hoc test) of doublecortin immunoreactive cells was observed in the subgranular zone of the dentate gyrus of rats treated 3 weeks with 2 mg kg−1 per day of WIN-55,212-2. (C) 5-bromo-2-deoxyuridine (BrdU)-positive cells in the DG of aged animals: a significant increase (63%, *P<0.05, Fisher's PLSD post-hoc test) of BrdU immunoreactive cells was observed in the subgranular zone of the dentate gyrus of rats treated for 3 weeks with 2 mg kg−1 per day of WIN-55,212-2. (D) Proportion of neurons/glia co-localized with BrdU cells in the DG of aged animals: no significant changes could be seen in the proportion of new neurons over new glial cells.
See this image and copyright information in PMC

References

    1. Klein TW. Nat Rev Immunol. 2005. pp. 400–411. - PubMed
    1. Marchalant Y, Rosi S, Wenk GL. Neuroscience. 2007. pp. 1516–1522. - PMC - PubMed
    1. Marchalant Y, Cerbai F, Brothers HM, Wenk GL. Neurobiol Aging. 2008. pp. 1894–1901. - PMC - PubMed
    1. Marchalant Y, Brothers HM, Norman G, Karelina K, Devries AC, Wenk GL. Neurobiol Dis. 2009. pp. 300–307. - PubMed
    1. Pertwee RG. Handbook Exp Pharmacol. 2005. pp. 1–51. - PubMed

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