Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Dec;10(12):833-44.
doi: 10.1038/nrg2683.

The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs

Alain Jacquier  1
Affiliations
Review

The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs

Alain Jacquier. Nat Rev Genet. 2009 Dec.

Abstract

Over the past few years, techniques have been developed that have allowed the study of transcriptomes without bias from previous genome annotations, which has led to the discovery of a plethora of unexpected RNAs that have no obvious coding capacities. There are many different kinds of products that are generated by this pervasive transcription; this Review focuses on small non-coding RNAs (ncRNAs) that have been found to be associated with promoters in eukaryotes from animals to yeast. After comparing the different classes of such ncRNAs described in various studies, the Review discusses how the models proposed for their origins and their possible functions challenge previous views of the basic transcription process and its regulation.

PubMed Disclaimer

References

    1. Nat Rev Genet. 2007 Jun;8(6):413-23 - PubMed
    1. Nat Rev Genet. 2009 Mar;10(3):155-9 - PubMed
    1. PLoS Genet. 2008 Dec;4(12):e1000299 - PubMed
    1. Nature. 2005 Aug 11;436(7052):876-80 - PubMed
    1. Nature. 2008 Jul 3;454(7200):126-30 - PubMed

Substances

LinkOut - more resources