Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Feb 6:2:145-50.
doi: 10.2147/dddt.s3255.

Surface activity of surfactant spiked with vitamin A

Vadim Bronshtein  1 , Vugranam Venkatesh, Jas Aulakh, Philippe Chessex
Affiliations

Surface activity of surfactant spiked with vitamin A

Vadim Bronshtein et al. Drug Des Devel Ther. .

Abstract

Background: Intramuscular injections of vitamin A decrease the risk of broncho-pulmonary dysplasia. Admixture of vitamin A with surfactant as a lipophilic vehicle might be a less invasive modality.

Aim: Test physical properties of surfactant + vitamin A.

Methods: Miscibility and surface activity were tested in surfactant supplemented with retinyl-acetate, -palmitate, 13-cis-, or all-trans-retinoic acid.

Results: Retinol acetate (5000 IU/mL) demonstrated miscibility with surfactant when premixing with ethanol. Its surface activity was 40% lower compared to surfactant alone.

Conclusion: These findings warrant preclinical studies to test whether administration of vitamin A in subjects requiring surfactant is associated with beneficial functional properties.

Keywords: drug delivery; surface tension; surfactant; vitamin A.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Surface tension properties of surfactant (BLES®). Maximum (max) and minimum (min) surface tension (nN/m) as determined by pulsating bubble meter in three runs as the bubble formed at the surface of the air/surfactant interface is subject to 20 pulsations per minute for 2 ½ minutes. After 25 pulsations the surface tension reaches a minimum of 2 ± 2 nN/m.
Figure 2
Figure 2
Surface tension properties of the mixture surfactant + retinly acetate + alcohol. Maximum (max) and minimum (min) surface tension (nN/m) as determined by pulsating bubble meter in three runs as the bubble formed at the surface of the air/surfactant admixture interface is subject to 20 pulsations per minute for 2 ½ minutes. After 25 pulsations the surface tension reaches a minimum of 13 ± 4 nN/m.
See this image and copyright information in PMC

References

    1. Allwood MC, Martin HJ. The photodegradation of vitamins A and E in parenteral nutrition mixtures during infusion. Clin Nutr. 2000;19:339–42. - PubMed
    1. Ambalavan N, Wu TJ, Tyson JE, et al. A comparison of three vitamin A dosing regimens in extremely-low-birth-weight-infants. J Pediatr. 2003;142:656–61. - PubMed
    1. Ambalavanan N, Kennedy K, Tyson J, et al. Survey of vitamin A supplementation for extremely-low-birth-weight infants: is clinical practice consistent with the evidence? J Pediatr. 2004;145:304–7. - PubMed
    1. Bernhard W, Mottaghian J, Gebert A, et al. Commercial versus native surfactants. Surface activity, molecular components, and the effect of calcium. Am J Respir Crit Care Med. 2000;162:1524–33. - PubMed
    1. Biesalski HK, Reifen R, Furst RP, et al. Retinyl palmitate supplementation by inhalation of an aerosol improves vitamin A status of preschool children in Gondar (Ethiopia) Br J Nutr. 1999;82:179–82. - PubMed

LinkOut - more resources