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. 2010 Mar;127(3):295-301.
doi: 10.1007/s00439-009-0769-8.

The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study

Nora Franceschini  1 , V Saroja Voruganti, Karin Haack, Laura Almasy, Sandy Laston, Harald H H Goring, Jason G Umans, Elisa T Lee, Lyle G Best, Richard R Fabsitz, Jean W MacCluer, Barbara V Howard, Kari E North, Shelley A Cole
Affiliations

The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study

Nora Franceschini et al. Hum Genet. 2010 Mar.

Abstract

Chronic kidney disease (CKD) is an important public health problem in American Indian populations. Recent research has identified associations of polymorphisms in the myosin heavy chain type II isoform A (MYH9) gene with hypertensive CKD in African-Americans. Whether these associations are also present among American Indian individuals is unknown. To evaluate the role of genetic polymorphisms in the MYH9 gene on kidney disease in American Indians, we genotyped 25 SNPs in the MYH9 gene region in 1,119 comparatively unrelated individuals. Four SNPs failed, and one SNP was monomorphic We inferred haplotypes using seven SNPs within the region of the previously described E haplotype using Phase v2.1. We studied the association between 20 MYH9 SNPs with kidney function (estimated glomerular filtration rate, eGFR) and CKD (eGFR\60 ml/min/1.73 m(2) or renal replacement therapy or kidney transplant) using age-, sex- and center-adjusted models and measured genotyped within the variance component models. MYH9 SNPs were not significantly associated with kidney traits in additive or recessive genetic adjusted models. MYH9 haplotypes were also not significantly associated with kidney outcomes. In conclusion, common variants in MYH9 polymorphisms may not confer an increased risk of CKD in American Indian populations. Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians.

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Conflict of interest statement

Conflict of interest statement None reported.

Figures

Fig. 1
Fig. 1
Linkage disequilibrium of genotyped SNPs of the MYH9 gene. SNPs are displayed in the left column ordered by position in base-pair. Right column shows the correlation among SNPs based on r2
Fig. 2
Fig. 2
Location of the SNPs genotyped within the MYH9 gene and flanking regions using NCBI Build 36.1(a). The figure also shows previously published SNPs genotyped in African-Americans (Published SNPs). Position of SNPs used to infer haplotypes (Phase v2.1) in the chromosome 22 region between 35019747 and 350334683 bp (b). The three most common haplotypes are displayed (SNP order: rs5756129, rs5756130, rs9619601, rs2239781, rs2157256, rs3830104, and rs3752462). P values for association of haplotype copies and kidney outcomes are also displayed. ACR albumin to creatinine ratio; eGFR estimated glomerular filtration rate; CKD chronic kidney disease
See this image and copyright information in PMC

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