Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1991 Jan;34(1):7-12.
doi: 10.1021/jm00105a002.

Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols

M L Hoefle  1 , L T Blouin, R W Fleming, S Hastings, J M Hinkley, T E Mertz, T J Steffe, C S Stratton, L M Werbel
Affiliations
Comparative Study

Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols

M L Hoefle et al. J Med Chem. 1991 Jan.

Abstract

A series of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols was evaluated for antiarrhythmic activity in the coronary artery ligated dog model. Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group afforded the best antiarrhythmic agents in this series and was essential for long duration of action. This investigation indicated that quaternary ammonium salts were not essential for a long duration of action. It was also shown that the antiarrhythmic activity could be separated from the tachycardia frequently caused by this type of agent.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Fine mapping of candidate effector genes for heart rate.
    Ramírez J, van Duijvenboden S, Young WJ, Chen Y, Usman T, Orini M, Lambiase PD, Tinker A, Bell CG, Morris AP, Munroe PB. Ramírez J, et al. Hum Genet. 2024 Oct;143(9-10):1207-1221. doi: 10.1007/s00439-024-02684-z. Epub 2024 Jul 6. Hum Genet. 2024. PMID: 38969939 Free PMC article.

Publication types

MeSH terms