Developmental ECM sculpting: laying it down and cutting it up
- PMID: 19922863
- DOI: 10.1016/j.devcel.2009.10.020
Developmental ECM sculpting: laying it down and cutting it up
Abstract
In mammals, proteolytic remodeling of the embryonic extracellular matrix (ECM) controls morphogenesis, but the key players remain elusive. Two recent reports identify new roles for metalloproteinases belonging to the MT-MMP and ADAMTS families in branching morphogenesis and interdigital web regression.
Comment on
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ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.Dev Cell. 2009 Nov;17(5):687-98. doi: 10.1016/j.devcel.2009.09.008. Dev Cell. 2009. PMID: 19922873 Free PMC article.
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