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. 1991 Jan 31;349(6308):388-93.
doi: 10.1038/349388a0.

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

D Broek  1 , R Bartlett, K Crawford, P Nurse
Affiliations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

D Broek et al. Nature. .

Abstract

Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.

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