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Review

. 2009 Dec;29(12):1986-8.

doi: 10.1161/ATVBAHA.109.198929.

Tissue factor: past, present, and future

Nigel Mackman¹, Mark Taubman

Affiliations

PMID: 19923557
PMCID: PMC2848486
DOI: 10.1161/ATVBAHA.109.198929

Review

Tissue factor: past, present, and future

Nigel Mackman et al. Arterioscler Thromb Vasc Biol. 2009 Dec.

. 2009 Dec;29(12):1986-8.

doi: 10.1161/ATVBAHA.109.198929.

Authors

Nigel Mackman¹, Mark Taubman

Affiliation

¹ Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7035, USA. nmackman@med.unc.edu

PMID: 19923557
PMCID: PMC2848486
DOI: 10.1161/ATVBAHA.109.198929

No abstract available

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Figures

Figure
TF coagulant and signaling activities. The TF coagulant activity involves the generation of thrombin, fibrin deposition, and platelet activation. The TF signaling activity involves activation of PAR-2 by FVIIa and FXa, as well activation of PAR-1 by FXa and thrombin.

See this image and copyright information in PMC

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References

1. Broze GJ, Leykam JE, Schwartz BD, Miletich JP. Purification of human brain tissue factor. J Biol Chem. 1985;260:10917–10920. - PubMed
1. Spicer EK, Horton R, Bloem L, Bach R, Williams KR, Guha A, Kraus J, Lin TC, Nemerson Y, Konigsberg WH. Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA. Proc Natl Acad Sci U S A. 1987;84:5148–5152. - PMC - PubMed
1. Morrissey JH, Fakhrai H, Edgington TS. Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell. 1987;50:129–135. - PubMed
1. Scarpati EM, Wen D, Broze JGJ, Miletich JP, Flandermeyer RR, Siegel NR, Sadler JE. Human tissue factor: cDNA sequence and chromosome localization of the gene. Biochemistry. 1987;26:5234–5238. - PubMed
1. Mackman N, Morrissey JH, Fowler B, Edgington TS. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry. 1989;28:1755–1762. - PubMed

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