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. 2009 Nov 3;14(11):4414-24.
doi: 10.3390/molecules14114414.

Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep

Supaluk Prachayasittikul  1 , Patumporn Manam, Maneekarn Chinworrungsee, Chartchalerm Isarankura-Na-Ayudhya, Somsak Ruchirawat, Virapong Prachayasittikul
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Bioactive azafluorenone alkaloids from Polyalthia debilis (Pierre) Finet & Gagnep

Supaluk Prachayasittikul et al. Molecules. .

Abstract

This study investigated bioactive extracts of Polyalthia debilis (Annonaceae) with antimicrobial, antimalarial and cytotoxic activities. Extensive chromatographic isolations provided azafluorenone alkaloids; onychine (1) and 7-methoxyonychine (2) together with a mixture of beta-sitosterol and stigmasterol. The two alkaloids were isolated from the P. debilis for the first time. Isolated fractions containing a mixture of triterpenoids (C7, C8 and C9) exhibited the most potent antimicrobial activity against many bacterial strains with minimum inhibitory concentration of 64 microg/mL. Fractions with antimalarial and cytotoxic activities were also observed. The findings suggest the potential use of P. debilis in medicinal applications.

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Figures

Figure 1
Figure 1
Chemical structures and numbering of alkaloids 1 and 2.
See this image and copyright information in PMC

References

    1. Smitinund T. Thai Plant Names (Botanical Names-Vernacular Names) Funny Publishing; Bangkok: 2001. p. 424.
    1. Kanokmedhakul S., Kanokmedhakul K., Yodbuddee D., Phonkerd N. New antimalarial bis-dehydroaporphine alkaloids from Polyalthia debilis. J. Nat. Prod. 2003;66:616–619. doi: 10.1021/np020498d. - DOI - PubMed
    1. De Almeida M.E.L., Braz F.R., von Bülow V., Gottlieb O.R., Maia J.G.S. Onychine, an alkaloid from Onychopetalum amazonicum. Phytochemistry. 1976;15:1186–1187. doi: 10.1016/0031-9422(76)85134-5. - DOI
    1. Waterman P.G., Muhammad I. Sesquiterpenes and alkaloids from Cleistopholis patens. Phytochemistry. 1985;24:523–527.
    1. Chakrabarty M., Patra A. 6,7- Dimethoxyonychine and other alkaloids of Polyalthia longifolia. Indian J. Chem. 1990;29B:394–395.

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