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. 2010 Apr;130(4):1185-8.
doi: 10.1038/jid.2009.367. Epub 2009 Nov 19.

Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis

Roshan Gunathilake, Matthias Schmuth, Tiffany C Scharschmidt, Robert Gruber, Daniela Grabher, Kieron S Leslie, Toby A Maurer, Theodora M Mauro, Peter M Elias

Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis

Roshan Gunathilake et al. J Invest Dermatol. 2010 Apr.
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Figures

Figure 1
Figure 1. Abnormal barrier function in HIV patients, independent of anti-retroviral therapy
(a) HIV+ patients displayed abnormal basal barrier function that became more prominent in a subgroup with xerotic eczema. Basal TEWL was measured in the interscapular skin using Tewameter at ambient clinic temperatures (22–25°C) and at a relative humidity of 40–60% after 15 minutes acclimatization. HIV patients displayed higher basal TEWL rates, which increased further in patients with xerotic eczema. (b) Abnormal barrier function in HIV+ patients is not attributable to antiretroviral therapy. HIV+ patients displayed abnormal basal barrier function, regardless of their antiretroviral treatment status. Abbreviation: TEWL, transepidermal water loss.
Figure 2
Figure 2. Patients with HIV-related xerotic eczema displayed lower SC hydration and higher pH, but comparable SC integrity and barrier recovery kinetics
Stratum corneum (SC) hydration of the interscapular skin was measured using corneometer. Surface pH was measured with a flat-glass electrode attached to a precision pH meter. SC integrity was assessed as the percentage increase in the TEWL after sequential tape stripping with 15 D-squame tapes. TEWL was read at 3 hours after tape stripping and barrier recovery was calculated as described in text. The dotted lines indicate mean values for control subjects. Abbreviation: TEWL, transepidermal water loss.
Figure 3
Figure 3. CD4+ nadir <150 μl−1 correlated with higher subject- and physician-rated skin dryness
Subjects and physicians were asked to rate skin dryness using a visual skin dryness scale (0–4). Subjects with CD4+ nadir <150 μl−1 displayed higher subject- and physician-rated dryness scores.
See this image and copyright information in PMC

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