Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009;33 Suppl 1(Suppl 1):S24-8.
doi: 10.1002/gepi.20468.

Haplotype-based analysis: a summary of GAW16 Group 4 analysis

Elizabeth Hauser  1 , Nadine Cremer, Rebecca Hein, Harshal Deshmukh
Affiliations

Haplotype-based analysis: a summary of GAW16 Group 4 analysis

Elizabeth Hauser et al. Genet Epidemiol. 2009.

Abstract

In this summary article, we describe the contributions included in the haplotype-based analysis group (Group 4) at the Genetic Analysis Workshop 16, which was held in September 17-20, 2008. Our group applied a large number of haplotype-based methods in the context of genome-wide association studies. Two general approaches were applied: a two-stage approach that selected significant single-nucleotide polymorphisms (SNPs) in the first stage and then created haplotypes in the second stage and genome-wide analysis of smaller sets of SNPs selected by sliding windows or estimating haplotype blocks. Genome-wide haplotype analyses performed in these ways were feasible. The presence of the very strong chromosome 6 association in the North American Rheumatoid Arthritis Consortium data was detected by every method, and additional analyses attempted to control for this strong result to allow detection of additional haplotype associations.

PubMed Disclaimer

References

    1. Abo R, Knight S, Wong J, Cox A, Camp NJ. hapConstructor: automatic construction and testing of haplotypes in a Monte Carlo framework. Bioinformatics. 2008;24:2105–7. - PMC - PubMed
    1. Allen AS, Satten GA. Genome-wide association analysis of rheumatoid arthritis data via haplotype sharing. BMC Proc. 3(Suppl 7):S30. - PMC - PubMed
    1. Balding DJ. A tutorial on statistical methods for population association studies. Nat Rev Genet. 2006;7:781–91. - PubMed
    1. Caillat-Zucman S. Molecular mechanisms of HLA association with autoimmune diseases. Tissue Antigens. 2009;73:1–8. - PubMed
    1. Campbell MC, Tishkoff SA. African genetic diversity: Implications for human demographic history, modern human origins, and complex disease mapping. Annu Rev Genomics Hum Genet. 2008;9:403–33. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources