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. 2009 Feb;20(2):99-108.
doi: 10.3766/jaaa.20.2.3.

Input and output compensation for the cochlear traveling wave delay in wide-band ABR recordings: implications for small acoustic tumor detection

Manuel Don  1 , Claus Elberling, Erin Maloff
Affiliations

Input and output compensation for the cochlear traveling wave delay in wide-band ABR recordings: implications for small acoustic tumor detection

Manuel Don et al. J Am Acad Audiol. 2009 Feb.

Abstract

Background: The Stacked ABR (auditory brainstem response) attempts at the output of the auditory periphery to compensate for the temporal dispersion of neural activation caused by the cochlear traveling wave in response to click stimulation. Compensation can also be made at the input by using a chirp stimulus. It has been demonstrated that the Stacked ABR is sensitive to small tumors that are often missed by standard ABR latency measures.

Purpose: Because a chirp stimulus requires only a single data acquisition run whereas the Stacked ABR requires six, we try to evaluate some indirect evidence justifying the use of a chirp for small tumor detection.

Research design: We compared the sensitivity and specificity of different Stacked ABRs formed by aligning the derived-band ABRs according to (1) the individual's peak latencies, (2) the group mean latencies, and (3) the modeled latencies used to develop a chirp.

Results: For tumor detection with a chosen sensitivity of 95%, a relatively high specificity of 85% may be achieved with a chirp.

Conclusion: It appears worthwhile to explore the actual use of a chirp because significantly shorter test and analysis times might be possible.

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Figures

Figure 1
Figure 1
Cumulative distributions for the NTNH individuals of the ratio of the Stacked ABR amplitude to the click-alone ABR amplitude for each of the latency compensation methods: (A) individual latencies, (B) mean latencies, and (C) modeled latencies.
Figure 2
Figure 2
Cumulative distributions and histograms of the normalized Stacked ABR wave V amplitude for the NTNH (gray) and SAT (hatched) populations based on the individual’s derived band wave V peak latencies. 95% sensitivity yields 92.0% specificity.
Figure 3
Figure 3
Cumulative distributions and histograms of the normalized Stacked ABR wave V amplitude for the NTNH (gray) and SAT (hatched) populations based on the mean derived band wave V peak latencies of the NTNH group. 95% sensitivity yields 85.0% specificity.
Figure 4
Figure 4
Cumulative distributions and histograms of the normalized Stacked ABR wave V amplitude for the NTNH (gray) and SAT (hatched) populations based on the modeled derived band wave V peak latencies of the NTNH group (Elberling et al, 2007). 95% sensitivity yields 85.4% specificity.
See this image and copyright information in PMC

References

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